Person / Position responsible in Work Center & Person Responsible in Order Header / Operations general data tab are totally different.
Person / Position Responsible in Work Center will be derived from Configuration whereas Person Responsible in Order header / Operations general data will be derived from HRMS assignment to Work center. HRMS assignment would be done using Employee master.
Both are in completely different source. As you have assigned 5 people through HRMS, what would be your logic to define the Person Responsible in Order header / Operations??
May be, based on Personnel designation in Employee Master, you can define the Person in Order Header / Operations. If same designation applies more than one person at a specific point of time, what would be your logic??
Even with development, it would be fuzzy logic but code may look simple. Its advisable to go for manual selection of Person at Order header / Operations / even at Confirmations.